Buoyed by Chaplin's tenor vocals and Rice-Oxley's inventive keyboard effects, the group made its studio debut in 2000 with a self-released single, Call Me What You Like. Wolf at the Door followed one year later, but the band still struggled to find its momentum as Scott left the lineup in July, leaving the band without a guitarist. Keane continued performing as a trio and happened upon their big break in December 2002, when Fierce Panda Records representative Simon Williams (who had helped discover Coldplay several years prior) was summoned by a friend to attend a Keane gig in London. Williams was impressed with the band's performance and offered to issue Keane's next single, Everybody's Changing, on the spot. The limited-edition release became a success on U.K. radio and attracted attention from major record labels, several of whom began to swarm around the group.

Keane signed with Island Records in 2003 and released This Is the Last Time, the band's final single for the Fierce Panda label, before the year was up. They made their major-label debut one year later with Hopes and Fears, which hit the top of the U.K. album charts during its first week of release and beat out Morrissey's You Are the Quarry. The ballad "Somewhere Only We Know" became a hit on both sides of the Atlantic, and Keane received two Brit Awards (for Best Breakthrough Act and Best Album 2005) while earning a Grammy nomination for Best New Artist. The album went on to become the second highest-selling record of the year in the U.K., barely losing out to the Scissor Sisters' debut.

Keane opened several shows during U2's 2005 tour in support of their debut, which was followed several months later by the Live Recordings 2004 EP. When it came time to return to the recording studio, the band once again enlisted producer Andy Green and fashioned a darker album titled Under the Iron Sea. Arriving in 2006, it debuted at number four on the Billboard Top 200, topped the U.K. charts, and spun off the band's most successful single to date with Is It Any Wonder? Keane chose to pursue a different agenda for their next project, however, returning in 2008 with a slightly retooled sound -- including the presence of electric guitar -- and a new album, Perfect Symmetry. Two years later, they changed directions yet again with the release of Night Train, an eight-song EP featuring collaborations with the Somali rapper K'NAAN. Released in 2012, Strangeland, the full-length follow-up to Perfect Symmetry, married that album’s use of guitars and über-pop sensibility with the anthemic, piano-led sound prevalent on the band’s first two albums, particularly Under the Iron Sea.